The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery
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چکیده
منابع مشابه
The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery†
Recently, our in silico repositioning-chemogenomics approach predicted paroxetine (PAR), an antidepressant drug, as a inhibitor of Schistosoma mansoni serotonin transporters (SmSERTs), and consequently, a new anti-schistosomal candidate. With the aim of determining the anti-schistosomal activity of this drug, we initially used a spectrophotometric assay to determine activity against schistosomu...
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Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been reported to have an effect on several ion channels including human ether-a-go-go-related gene in a SSRI-independent manner. These results suggest that paroxetine may cause side effects on cardiac system. In this study, we investigated the effect of paroxetine on Kv1.5, which is one of cardiac ion channels. The action of parox...
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ژورنال
عنوان ژورنال: MedChemComm
سال: 2016
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c5md00596e